In Reply: Trough Melatonin Levels Have No Physiological or Clinical Relevance

-chemokines Have Clinical Relevance in HIV Infection?

The role of b -chemokines in HIV infection was evaluated. The kinetics of regulated upon activation of normal T cell expressed and secreted, macrophage inflammatory protein1 a , and macrophage inflammatory protein 1 b production by stimulated T lymphocytes did not differ substantially between HIV-infected (asymptomatic and with AIDS) and uninfected subjects. Maximal production of these b -chemo...

Vancomycin Trough Levels: Cause or Result of Acute Kidney Injury?

clearance of vancomycin to the clearance of the gold standard glomerular filtration rate (GFR) marker inulin is 0.89 in normal volunteers at steady state with endogenous creatinine as a filtration marker the ratio is 0.79 [5] . Therefore, the vancomycin clearance is a better GFR marker than is the creatinine clearance. Thus the interpretation of trough levels needs to be based on the renal func...

Contraction-excitation feedback in myocardium. Physiological basis and clinical relevance.

The clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study.

This retrospective multicenter study in patients with chronic myeloid leukemia in chronic phase was undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given at a fixed 400mg daily dose. A significant inverse relationship of imatinib con...

Cyclosporine trough levels in renal graft recipients.

Blood Trough Levels (TL) of cyclosporine (CyA) [the drug panimun bioral cyclosporine oral solution USP--modified. Panacea Biotec Ltd], were monitored in 103 renal transplant patients who were receiving CyA orally. Two hundred and sixty-two blood concentrations of CyA were determined using a validated HPLC assay over a period of two years. Mean dose from week 1 until 2 years ranged from 7.65 +/-...